Intrinsic nucleic acid dynamics modulates HIV-1 nucleocapsid protein binding to its targets.
HIV-1 nucleocapsid protein (NC) is involved in the rearrangement of nucleic acids occurring in key steps of reverse transcription.The protein, through its two zinc fingers, interacts preferentially with unpaired guanines in single-stranded sequences.In mini-cTAR stem-loop, which corresponds to the top half of the cDNA copy of the transactivation re